Article,
Entering the Next Phase: Predicting Biological Effects of Biomolecular Condensates
Affiliations
- [1] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
- [2] Nordic EMBL Partnership for Molecular Medicine [NORA names: Miscellaneous; Denmark; Europe, EU; Nordic; OECD]
Abstract
Biomolecular condensates are increasingly recognized as important drivers of cellular function; their dysregulation leads to pathology and disease. We discuss three questions in terms of the impending utility of data-driven techniques to predict condensate-driven biological outcomes, i.e., the impact of cellular state changes on condensates, the effect of condensates on biochemical processes within, and condensate properties that result in cellular dysregulation and disease.
Keywords
biomolecular condensates,
emergent properties,
phase-separation regulation,
predictive machine learning