Short Survey,
Towards fair and clinically relevant polygenic predictions
Contributors
Vilhjalmsson B.J.
0000-0003-2277-9249
(Corresponding author)
[1]
[2]
Affiliations
- [1] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
- [2] Broad Institute of MIT and Harvard [NORA names: United States; America, North; OECD]
Abstract
Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models.
Keywords
clinical risk assessment,
diverse ancestry,
polygenic scores
