Note, 2024

Carnosine facilitates lysosomal release of inhibitors of T cell surveillance

Cell Metabolism, ISSN 1550-4131, 1932-7420, Volume 36, 3, Pages 461-462, 10.1016/j.cmet.2024.02.003

Contributors

Swietach P. 0000-0002-9945-9473 (Corresponding author) [1] Jaattela M. 0000-0001-5950-7111 Pillon-Thomas S. [2] Boedtkjer E. 0000-0002-5078-9279 [3]

Affiliations

  1. [1] University of Oxford
    2. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  2. [2] Moffitt Cancer Center
    3. [NORA names: United States; America, North; OECD];
  3. [3] Aarhus University
    4. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Cancer metabolism produces large fluxes of lactate and H, which are extruded by membrane transporters. However, H production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.

Data Provider: Elsevier

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