Article,
Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca-Binding Motif
Contributors
Ortiz-Lopez F.J.
0000-0002-9410-3718
(Corresponding author)
[1]
Oves-Costales D.
0000-0001-9986-4623
(Corresponding author)
[1]
Reyes F.
0000-0003-1607-5106
[1]
Weber T.
0000-0002-8260-5120
[2]
Genilloud O.
0000-0002-4202-1219
[1]
Affiliations
- [1] Fundación MEDINA [NORA names: Spain; Europe, EU; OECD];
- [2] Technical University of Denmark [NORA names: DTU Technical University of Denmark; University; Denmark; Europe, EU; Nordic; OECD]
Abstract
Genome analysis of strain Streptomyces sp. CA-278952 revealed a biosynthetic gene cluster encoding a putative lipopeptide with a sequence containing an Asp-Gly-Glu-Ala motif. We envisioned that this motif could mimic the canonical Asp-X-Asp-Gly sequence found in previously reported calcium-dependent lipopeptide antibiotics. Chemical investigation of the producing strain led to the discovery of three novel lipodepsipeptides, dilarmycins A-C. The calcium-dependent antibacterial activity of the new compounds was confirmed against the Gram-positive pathogens methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
