Chapter,
Type XX collagen
,
Editors:
DOI:
Affiliations
- [1] Nordic Bioscience [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]
Abstract
Type XX collagen is assigned to the fibril-associated collagens with interrupted triple helices collagen subfamily due to its similarities with type XII and XIV collagens. The tissue distribution is relatively large and elevated in different types of cancer. Structurally, type XX collagen is made up of six fibronectin type III repeat domains, a von Willebrand factor A domain, a laminin G-like domain (also known as the thrombospondin domain), and two triple-helical domains. The function of type XX collagen is largely unknown, and good tools are needed to investigate and quantify its biological role.
Keywords
Brain function,
COL20A1,
Cancer,
Collagen,
Extracellular matrix,
FACIT,
PRO-C20,
Post-translational modifications,
Tumor tissue,
Type XX collagen