Article,
Delivery of a sebum modulator by an engineered skin microbe in mice
Contributors
Manils J.
0000-0001-8429-1295
[2]
[3]
Carolis C.
0000-0003-4240-1139
Zouboulis C.C.
0000-0003-1646-2608
[5]
Soler C.
0000-0001-6502-5012
[2]
[3]
Lood R.
0000-0002-5974-0674
[6]
Bruggemann H.
0000-0002-2473-6202
[7]
Guell M.
0000-0003-4000-7912
(Corresponding author)
[1]
[8]
Affiliations
- [1] Universitat Pompeu Fabra [NORA names: Spain; Europe, EU; OECD];
- [2] Catalan Institute of Oncology [NORA names: Spain; Europe, EU; OECD];
- [3] University of Barcelona [NORA names: Spain; Europe, EU; OECD];
- [4] Vall d'Hebron Institute of Oncology (VHIO) [NORA names: Spain; Europe, EU; OECD];
- [5] Brandenburg Medical School Theodor Fontane [NORA names: Germany; Europe, EU; OECD];
(... more)
Abstract
Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.
