Article,
Hybrid catalysis for enantioselective Baeyer-Villiger oxidation and stereoselective epoxidation: a Cp*Ir complex to fuel FMN and FAD reduction for flavoprotein monooxygenase modules
Contributors
Rollig R.
0000-0001-9940-6788
(Corresponding author)
[1]
Paul C.E.
0000-0002-7889-9920
[2]
Rousselot-Pailley P.
0000-0002-7658-9056
[1]
Kara S.
0000-0001-6754-2814
(Corresponding author)
[3]
[4]
Alphand V.
0000-0001-6855-7292
(Corresponding author)
[1]
Affiliations
- [1] CNRS [NORA names: France; Europe, EU; OECD];
- [2] Delft University of Technology [NORA names: Netherlands; Europe, EU; OECD];
- [3] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
- [4] Leibniz Universität Hannover [NORA names: Germany; Europe, EU; OECD]
Abstract
Taking advantage of the unique properties of two-component flavo-monooxygenases and the ability of [Cp*Ir(bpy-OMe)H] to transfer hydrides to reduce flavins, we extended the scope of the pH- and oxygen-robust iridium(iii)-complex to drive the enzymatic reaction of a FMN-dependent Baeyer-Villiger monooxygenase and a FAD-dependent styrene monooxygenase (respectively FPMO Group C and E), using formic acid as H-donor for NADH recycling.
